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Our current research lines
Macrophage targeting and modulation
We aim to understand the role and biology of tumor associated macrophages (TAM) in solid tumors and develop tools to modulate them for therapeutic purposes. We developed a family of peptides to target tumor associated macrophages (TAM) in various solid tumors in mice: breast cancer, glioblastoma, melanoma, gastric cancer.
Targeting glioblastoma and neuroendocrine tumors
We recently reported a new target in glioblastoma, the protein SNAP25. SNAP25 is part of the SNARE complex and is responsible for the fusion of vesicles (synaptic or hormone-containing) with the cell membrane, needed for exocytosis. SNAP25 is an intracellular protein in normal conditions, but in glioblastoma and neuroendocrine cancer we found that it becomes present on the cell surface and the vasculature
Art gallery
SNAP25 expression in human glioblastoma (brown)
Oral targeting of MACTIDE peptide (in green) to CD206+
tumor macrophages (in red) in breast cancer in mice
Phagocytosis of live cancer cells (green) by mice bone-marrow derived macrophages (blue)
SNAP25 (green) expression in STC-1
(mouse gastric neuroendocrine neoplasm)
CES peptide (green) colocalization to SNAP25+ (red) extracellular vesicles (yellow-ish)
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